Autism Spectrum Disorder May Be More Prevalent Among Children Born Very Prematurely

Science Daily (Jan. 30, 2009) Researchers from Boston University School of Medicine (BUSM) and Boston Medical Center (BMC), in collaboration with other medical centers, have found that children born more than three months premature, are at three times the risk for screening positive on the modified checklist for autism in toddlers (M-CHAT). Children who screen positive on M-CHAT may be at greater risk for developing autism.
The Council on Children with Disabilities of the American Academy of Pediatrics recommends that pediatricians screen for an autism spectrum disorder (ASD) if there are concerns about the child’s development. One of the ASD-specific screening tools is the M-CHAT. The M-CHAT is a checklist that asks the parent/caregiver to report on 23 behaviors. Checking any three items or two of six critical items as “unable to perform” leads to a positive screen on M-CHAT.

The researchers enrolled more than 1,500 infants born more than three months early at one of 14 hospitals in five states. An M-CHAT was completed by the nearly 1,000 caregivers of children who returned for follow-up evaluation at age 2.

According to the researchers, when an M-CHAT is used as a screen in unselected children during well-child care visits between 16 and 30 months of age, 5.7 percent screen positive. Overall, more than 21 percent of the children in this study screened positive. The study investigators found that the presence of multiple physical handicaps appears to contribute to screening positive, independent of true autism risk.

“However, in our study, even after excluding those children with motor, vision and hearing impairments, we still found 16 percent screened positive,” said lead author Karl Kuban, MD, SMEpi, a professor of pediatrics and neurology at BUSM and Chief, Division of Pediatric Neurology at BMC. “Because we have not yet determined if those who screened positive satisfy criteria for an ASD, we cannot yet assess the predictive values of the M-CHAT among children born at extremely low gestational ages,” he added.

Making a diagnosis of ASD often occurs after many years of symptoms, at times delaying appropriate services for children with the disorder. “Determining the predictive value for screening positive on the M-CHAT among extremely low gestational age children and among handicapped children may offer critical information for pediatricians, since the AAP has recommended early screening for autism,” added Kuban.


Funding for this study was provided by the National Institute of Neurological Disorders and Stroke.

Journal references:

Karl C. K. Kuban, MD, SM, Epi, T. Michael O’Shea, MD, MPH, Elizabeth N. Alfred, MS, Helen Tager-Flusberg, PhD, Donald J. Goldstein, PhD, Alan Leviton, M. Positive Screening on the Modified Checklist for Autism in Toddlers (M-CHAT) in Extremely Low Gestational Age Newborns. Journal of Pediatrics, January 2009 DOI:
10.1016/j.jpeds.2008.10.011 , Neil Marlow, MD, and Samantha Johnson, PhD. Positive Screening Results on the Modified Checklist for Autism in Toddlers: Implications for Very Preterm Populations. Journal of Pediatrics, January 2009 DOI: 10.1016/j.jpeds.2008.11.028

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