Prenatal Vitamins and Autism Spectrum Disorders

In a recent study, Dr. Rebecca J. Schmidt and colleagues suggest that their research findings reveal preliminary evidence that consuming prenatal vitamins during the three months prior to conception and the first month of pregnancy may decrease the risk of autism spectrum disorders (ASD), even for mothers and children with specific genetic predispositions. While it is likely that both genetic and environmental factors play a causal role in the development of ASD, little is known about how these factors interact. For this reason, Dr. Schmidt and colleagues set out to investigate correlations between the consumption of preconception and prenatal vitamins and the development of ASD, while also examining the involvement of various genetic predispositions.

Participants included 278 children with typical development, 288 children with autistic disorder, and 141 children with ASD, ages 24 to 60 months. Via telephone interviews, mothers were questioned retroactively about their consumption of vitamin supplements during the three months prior to conception and throughout the gestational period. Furthermore, blood samples were collected from the families of 232 participants with typical development and 238 participants with autistic disorder. Maternal, paternal, and child blood samples were tested for various one-carbon metabolism gene variations, which have been found in previous research studies to be associated with ASD.

The results revealed that mothers who consumed prenatal vitamins during the three months prior to conception and the first month of pregnancy were significantly less likely to have a child with ASD than those who did not. The finding also revealed:

  • a correlation between the risk of ASD and the frequency of prenatal vitamin intake during the three months prior to conception and the first month of pregnancy, with greater frequency indicating reduced risk
  • no correlation between the development of ASD and prenatal vitamin intake during the second through ninth month of gestation
  • no correlation between the development of ASD and regular multivitamin intake at the approximate time of conception

Moreover, significant correlations were found between the risk of ASD and prenatal vitamin intake during the three months prior to conception and the first month of pregnancy for specific gene variations, with a greater risk of ASD identified for mothers who did not report taking prenatal vitamins during this period. These gene variations included maternal MTHFR 677 TT and CBS rs234715 GT + TT, and child COMT 472 AA genotypes. On the contrary, an opposite effect was identified for the child MTHFR 677 TT genotype.

Dr. Schmidt and colleagues maintain that their finding provides preliminary evidence that taking prenatal vitamins three months prior to conception may reduce the risk of ASD, even for mothers and children with specific genetic predispositions. These findings appear to support the notion that both genetic and environmental factors play a causal role in the development of ASD. If replicable, this study offers a fairly simple precaution that women, who are planning for a pregnancy, can take in order to reduce the likelihood of having a child with ASD. Further research exploring the effect of prenatal vitamins on the development of ASD is warranted.

References

Schmidt, R. J., Hansen, R. L., Hartiala, J., Allayee, H., Schmidt, L. C., Tancredi, D. J., … Hertz-Picciotto, I. (2011). Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism. Epidemiology, 22,476-485. doi: 10.1097/EDE.0b013e31821d0e30

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  230. With havin so much content and articles do you ever run into any problems of plagorism or copyright violation? My site has a lot of completely unique content I’ve either authored myself or outsourced but it appears a lot of it is popping it up all over the web without my agreement. Do you know any techniques to help reduce content from being ripped off? I’d really appreciate it.

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  238. With havin so much written content do you ever run into any problems of plagorism or copyright infringement? My blog has a lot of exclusive content I’ve either authored myself or outsourced but it appears a lot of it is popping it up all over the internet without my authorization. Do you know any solutions to help protect against content from being ripped off? I’d truly appreciate it.

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  244. Hmm is anyone else encountering problems with the pictures on this blog loading? I’m trying to figure out if its a problem on my end or if it’s the blog. Any feed-back would be greatly appreciated.

  245. I was curious if you ever considered changing the page layout of your site? Its very well written; I love what youve got to say. But maybe you could a little more in the way of content so people could connect with it better. Youve got an awful lot of text for only having one or 2 pictures. Maybe you could space it out better?

  246. My developer is trying to persuade me to move to .net from PHP. I have always disliked the idea because of the expenses. But he’s tryiong none the less. I’ve been using Movable-type on a variety of websites for about a year and am worried about switching to another platform. I have heard excellent things about blogengine.net. Is there a way I can import all my wordpress content into it? Any help would be really appreciated!

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  257. My coder is trying to convince me to move to .net from PHP. I have always disliked the idea because of the costs. But he’s tryiong none the less. I’ve been using Movable-type on a number of websites for about a year and am worried about switching to another platform. I have heard excellent things about blogengine.net. Is there a way I can import all my wordpress content into it? Any kind of help would be really appreciated!

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  261. Howdy! Quick question that’s entirely off topic. Do you know how to make your site mobile friendly? My site looks weird when viewing from my iphone 4. I’m trying to find a theme or plugin that might be able to resolve this problem. If you have any recommendations, please share. Thank you!

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  264. I was curious if you ever considered changing the page layout of your website? Its very well written; I love what youve got to say. But maybe you could a little more in the way of content so people could connect with it better. Youve got an awful lot of text for only having 1 or two pictures. Maybe you could space it out better?

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  267. First of all I would like to say fantastic blog! I had a quick question that I’d like to ask if you do not mind. I was interested to know how you center yourself and clear your head before writing. I have had trouble clearing my thoughts in getting my ideas out. I do take pleasure in writing but it just seems like the first 10 to 15 minutes are usually wasted simply just trying to figure out how to begin. Any recommendations or tips? Appreciate it!

  268. I know this if off topic but I’m looking into starting my own weblog and was wondering what all is required to get setup? I’m assuming having a blog like yours would cost a pretty penny? I’m not very web smart so I’m not 100% sure. Any recommendations or advice would be greatly appreciated. Thanks

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  282. Hello! I just wanted to ask if you ever have any issues with hackers? My last blog (wordpress) was hacked and I ended up losing a few months of hard work due to no data backup. Do you have any methods to prevent hackers?

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  285. Hmm is anyone else experiencing problems with the images on this blog loading? I’m trying to determine if its a problem on my end or if it’s the blog. Any suggestions would be greatly appreciated.

  286. Hello there! Do you know if they make any plugins to assist with Search Engine Optimization? I’m trying to get my blog to rank for some targeted keywords but I’m not seeing very good results. If you know of any please share. Thanks!

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  288. My coder is trying to persuade me to move to .net from PHP. I have always disliked the idea because of the costs. But he’s tryiong none the less. I’ve been using Movable-type on several websites for about a year and am worried about switching to another platform. I have heard fantastic things about blogengine.net. Is there a way I can import all my wordpress posts into it? Any help would be really appreciated!

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  292. Hey I know this is off topic but I was wondering if you knew of any widgets I could add to my blog that automatically tweet my newest twitter updates. I’ve been looking for a plug-in like this for quite some time and was hoping maybe you would have some experience with something like this. Please let me know if you run into anything. I truly enjoy reading your blog and I look forward to your new updates.

  293. Fantastic blog! Do you have any hints for aspiring writers? I’m hoping to start my own site soon but I’m a little lost on everything. Would you suggest starting with a free platform like WordPress or go for a paid option? There are so many options out there that I’m completely confused .. Any suggestions? Thanks!

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  298. Hey there this is kind of of off topic but I was wondering if blogs use WYSIWYG editors or if you have to manually code with HTML. I’m starting a blog soon but have no coding know-how so I wanted to get guidance from someone with experience. Any help would be enormously appreciated!

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