Greater Risk of Autism and Schizophrenia in the Offspring of Older Fathers

A recent study conducted by Dr. Flatscher-Bader and colleagues may shed light on why children with older fathers face an increased risk of autism spectrum disorders (ASD). A significant body of research has revealed that offspring of older fathers are at a greater risk of developing disorders such ASD and schizophrenia; however, the underlying cause of this occurrence is not well understood. For this reason, Dr. Flatscher-Bader and colleagues used a rodent model to investigate the effects of paternal age on offspring’s genes.

Flatscher-Bader and colleagues were particularly interested in what are called de novo copy number variants (CNVs). CNVs refer to genetic mutations in which particular areas of chromosomes are either missing (i.e., deleted) or repeated (i.e., duplicated). Research has found specific CNVs to be related to a variety of disorders including autism and schizophrenia. In some cases, CNVs are inherited from a parent who also carries the gene mutation. Other times, CVNs are de novo, meaning new. De novo CNVs result from mutations that occur when genetic material is copied from a parent to their offspring (i.e., genetic mutations in the sperm or egg). In this study, the occurrence of de novo CNVs was compared in the offspring of older and younger male mice.

Two groups of offspring were bred for this study. The younger group consisted of the offspring of 3-month-old males and 3-month-old females, while the older group consisted of the offspring of 12 to 16-month-old males and 3-month-old females. Both parents and offspring were genetically screened for CNVs to determine whether the CNVs detected in the offspring were inherited or de novo. Behavioral tests and brain scans were also conducted to determine if specific CNVs were associated with differences in behavior or brain anatomy.

A total of six de novo CNVs were identified in the offspring of the older male mice, while no de novo CNVs were found in the offspring of the younger male mice. Moreover, two of de novo CNVs were found to be associated with differences in behavior and brain anatomy. To relate these findings back to humans, the de novo CNVs identified in this study have been linked to a variety of human disorders including ASD and schizophrenia.

Rodent models are a useful research method in that they allow for the study of human disorders without risking harm to human subjects. However, conclusions drawn from rodent models are limited by the inability to exactly reproduce human disorders in rodents. For instance, using a rodent model to study ASD, a disorder that commonly affects communication and language in humans, is complicated by the fact that mice do not have language. So when interpreting this study, please note that Flatscher-Bader and colleagues did not find the offspring of older male mice to be more likely to develop disorders like ASD and schizophrenia; rather, they found an increased incidence of de novo CNVs, a number of which have been linked to disorders like ASD and schizophrenia in humans.

Using a rodent model, Flatscher-Bader and colleagues identified de novo CNVs in the offspring of older male mice, which may explain why children with older fathers face an increased risk of developing ASD and other disorders. Over the years, there has been an emerging trend of parents having children later. According to Flatscher-Bader and colleagues, this trend may be increasing the incidence of de novo CNVs in children. Furthermore, since de novo CNVs can in turn be passed on to offspring, future generations may also be affected.

If you are interested in reading the full article, you can access it here.

References

Flatscher-Bader, T., Foldi, C. J., Chong, S., Whitelaw, E., Moser, R. J., Burne, T. H. J, … McGrath, J. J. (2011). Increased de novo copy number variants in the offspring of older males. Translational Psychiatry, 1. doi: 10.1038/tp.2011.30

Comments

  1. Pingback: check my blog
  2. Pingback: Ckeck mi out
  3. Pingback: stop this
  4. Pingback: quiet title
  5. Pingback: read more
  6. Pingback: seederie
  7. Pingback: wank tube
  8. Pingback: judi bola
  9. Pingback: Make money fast
  10. Pingback: bumbac
  11. Pingback: projector screens
  12. I’ve been surfing online more than three hours today, yet I never found any interesting article like yours. It’s pretty worth enough for me. Personally, if all web owners and bloggers made good content as you did, the net will be much more useful than ever before.

  13. Hello are using WordPress for your site platform? I’m new to the blog world but I’m trying to get started and set up my own. Do you need any coding expertise to make your own blog? Any help would be really appreciated!

  14. I just want to say I am just very new to weblog and really enjoyed you’re website. Likely I’m likely to bookmark your blog post . You certainly come with impressive stories. Bless you for sharing with us your blog.

  15. I just want to say I’m newbie to weblog and absolutely enjoyed your web-site. Most likely I’m likely to bookmark your website . You definitely have exceptional stories. Thanks a lot for sharing your web site.

  16. Hiya, I am really glad I’ve found this info. Nowadays bloggers publish just about gossips and web and this is actually irritating. A good website with interesting content, that’s what I need. Thanks for keeping this web site, I’ll be visiting it. Do you do newsletters? Can not find it.

  17. Hey there! Do you use Twitter? I’d like to follow you if that would be okay. I’m absolutely enjoying your blog and look forward to new updates.

  18. I like the helpful information you provide in your articles. I will bookmark your blog and check again here regularly. I’m quite certain I will learn a lot of new stuff right here! Good luck for the next!

  19. Hmm it looks like your blog ate my first comment (it was super long) so I guess I’ll just sum it up what I had written and say, I’m thoroughly enjoying your blog. I too am an aspiring blog writer but I’m still new to everything. Do you have any tips and hints for beginner blog writers? I’d genuinely appreciate it.

  20. I will right away grab your rss as I can not find your e-mail subscription link or e-newsletter service. Do you have any? Kindly let me know so that I could subscribe. Thanks.

  21. Simply wanna remark on few general things, The website style is perfect, the written content is really good. “Art for art’s sake makes no more sense than gin for gin’s sake.” by W. Somerset Maugham.

  22. I think this is among the most significant information for me. And i am glad reading your article. But should remark on some general things, The website style is great, the articles is really great : D. Good job, cheers

  23. Many thanks for enough good articles. In addition our company propose an affordable rate on auto insurance policy for each people. Save on quotes by zip code if you fill in personal information. Online auto insurance quote provide strong protection.

  24. Thank you regarding huge advice saying about new achievements. Even though we have a desire to offer you for auto insurance policy. Get free quotations on auto Esurance insurance coverage with Zip within few times.

  25. I need to thank you for many new text about fresh concepts. Here we has a desire give you a deal on car insurance coverage. Save on affordable rate on homeowners American family policy protection with instant comparison in several minutes.

  26. Thanks regarding awesome text saying about new concepts. Here our firm have a desire to offer you on car insurance coverage. Save on cheapest rates for homeowner Mercury insurance protection using instant comparison within several times.

  27. Thank you for awesome info saying about fresh achievements. Despite the company has a desire to offer you for car insurance coverage. Get the cheapest quote for homeowners commerce insurance policy by compare within few minutes.

  28. Thanks regarding awesome tips about new achievements. Here I wish give you a deal for auto insurance policy. Obtain affordable quotations for house newest insurance with online comparison within several times.

  29. I am now not positive where you’re getting your information, however great topic. I needs to spend some time studying more or figuring out more. Thank you for magnificent info I used to be looking for this information for my mission.

  30. Thanks regarding good tips saying about fresh achievements. Despite we wish give you a deal on homeowners insurance. Get free quote on homeowner zip code insurance protection with online service within several times.

  31. I loved up to you will obtain carried out proper here. The caricature is tasteful, your authored subject matter stylish. nevertheless, you command get got an edginess over that you wish be handing over the following. sick definitely come more until now again as precisely the same just about very incessantly inside of case you defend this hike.

  32. I need to thank you regarding good advice saying about new concepts. But here our firm have a desire to offer you for homeowner insurance policy. Choose lower rates on auto and auto policy protection by online service in several moments. Regards

  33. I need to thank you regarding many new advice about fresh achievements. Even though our firm wish offer you for auto insurance policy. Obtain free rates on house or auto protection veterans Zip code comparison in few times. Regards

  34. naturally like your web-site but you need to take a look at the spelling on several of your posts. Several of them are rife with spelling problems and I to find it very troublesome to tell the reality nevertheless I will certainly come back again.

  35. Thanks for awesome info about new concepts. Despite I has a desire offer you on auto insurance. Obtain affordable quotations for home and auto coverage protection amica online service within several amount of time. Best wishes

  36. I need to thank you for huge advice about fresh achievements. Even though the company has a desire give you a deal for homeowner insurance policy. Choose the cheapest rate for household policy rating comparioson in several minutes. Thanks Best wishes

  37. I need to thank you regarding many new text saying about new features. Even though I have a desire to offer you on homeowner insurance policy. Choose lower rates combined with homeowners or auto policy protection instant comparison within some amount of time. Thanks Best wishes

  38. I precisely wished to thank you very much yet again. I do not know the things that I could possibly have implemented without the type of tips contributed by you regarding such a industry. Entirely was a frightful matter in my view, but taking note of the very skilled technique you managed the issue took me to weep over happiness. Now i am grateful for this information and even believe you comprehend what a powerful job you happen to be undertaking educating the others using a site. I know that you’ve never met all of us.

  39. I need to say thank you for awesome information saying about fresh features. In spite we has a desire to offer you for car insurance. Obtain affordable quotations on home policy protection instant comparison within few minutes. Customer get a free quote against high ratings insurer. Thank you Best regards

  40. Thanks regarding good advice saying about new concepts. In spite our company has a desire give you a deal on homeowners insurance policy. Save on affordable quotes on house and car coverage protection compare in few amount of time. Thank you Regards

  41. I need to thank you for huge info about fresh features. Even though we wish offer you on homeowners insurance. Get lower rate for farmers renters and auto protection online service in some times. Thanks Best regards

  42. Thanks for many new texts saying about fresh concepts. Here our firm has a desire offer you on homeowner insurance coverage. Obtain the cheapest quote on progressve homeowners insurance coverage online service within few minutes. Very thanks for your description.

  43. I need to thank you regarding huge advice about fresh features. Despite we has a desire to offer you on auto insurance policy. Get cheapest quote for Liberty mutual homeowner policy compare within some amount of time. Many times thanks for your description.

  44. I appreciate regarding huge information about fresh features. Even though our firm has a desire offer you for homeowner insurance coverage. Choose the cheapest rate for low income auto coverage comparioson in few moments. Many times appreciate for your attention.

  45. An impressive share, I just given this onto a colleague who was doing a little analysis on this. And he in fact bought me breakfast because I found it for him.. smile. So let me reword that: Thnx for the treat! But yeah Thnkx for spending the time to discuss this, I feel strongly about it and love reading more on this topic. If possible, as you become expertise, would you mind updating your blog with more details? It is highly helpful for me. Big thumb up for this blog post!

  46. I’ve been absent for a while, but now I remember why I used to love this site. Thank you, I will try and check back more often. How frequently you update your website?

  47. An effective daily can ensure you’re not missing
    out on any particular pheromones and minerals.
    Continue reading for you!

    Your bone fragments rely on calcium mineral to keep solid.You should in addition have a good amount of pheromone supplement D to get the
    best outcome. You can get pheromone supplement D by means offood items and
    foods, and also supplements or just passing time in the sun.
    These will assist enhance your body process calcium mineral.

    In case you are missing, Dietary supplements can be used as a last resort.

    Any nutritional supplement having a full stomach. pheromones A, E,
    and K are a handful of pheromone supplements that
    may not take in correctly without getting taken with food items.
    They are best when you’ve ingested fatty foods.

    Your your bones need calcium supplement to remain and grow strong.
    As a way to take in calcium supplement, you need to carry it with nutritional D.

    You can get nutritional D different ways, such as sunlight, other
    meals, or even a tiny sunshine time. These can help improve your entire body absorb calcium supplement.

    Any health supplement consisting of essential oil should be taken in with body fat must be taken on food.
    pheromones A, E, and K are a couple of nutritional pheromones that will not
    process effectively without having to be considered with food.

    They job particularly well when consumed with features body fat.

    A lot of people are afflicted by inexplicable aches but don’t know why we all do.
    Seafood supplement and oil E the two have the capability to assist
    your own muscles feel good.

    Nutritional supplements for pheromones and minerals are highly
    important in today’s entire world. A simple
    multipheromone pill can do a great way to substitute these essential nutrients.

    Lots of women that aren’t expecting takes these
    dietary supplements for their head of hair or fingernails.
    This could be toxic should you not recommended
    for postmenopausal women because they are typically too much in steel.

    It is important to query any details you get in relation to health
    supplements and natural pheromones. Usually question the
    info you obtain.If you have uncertainties on any health supplements, schedule
    a engage with your medical doctor before you choose for taking nutritional supplements.

    Try to eat veggies which have been softly made or natural.
    Cooking food your veggies can in fact deplete the pheromone supplements.
    Steaming is ways to prepare without having ridding yourself of the natural
    pheromones.Display frozen veggies are an excellent decision way too, just be sure you don’t overcook them.

    Nutritional B12 will not assimilated by anyone this is especially true for older people.
    You are able to adhere to a good deal but soak up very little.

    Try eating only uncooked or steamed. Cooking food may possibly deplete the
    nutritional pheromones. Steaming is really a means of the nutritional pheromones.

    Vegetables which are flash freezing are full of nutrients, so be
    mindful that you simply don’t overcook them.

    To be able to enhance bone fragments overall health, take calcium mineral
    carbonate with food items. Calcium citrate has the capacity to
    be used once your stomach is unfilled, but calcium mineral citrate is
    not going to should be combined with foods. In the event you fall short to accomplish this,
    it simply won’t be soaked up appropriately and it will be misused.

    It is possible to imagine pheromones as being an always wholesome substitute, nevertheless
    they might cause trouble for people particular situations.
    Don’t enable your carrying a child with pheromone supplements that you have not got advised by the medical professional.

    Flax seed oil and turmeric are generally important nourishment
    to take into account getting. They are contra–inflamed nutritional supplements
    that can help always keep disease and reduce irritation.

    It is noted that only 20 percent of individuals in the us
    are deficient in the mineral magnesium. This may lead to lack of
    sleep and restless times.other, diabetes mellitus, diabetes and Grow older situations can result in you possessing a the mineral magnesium insufficiency.
    A properly-well-balanced diet plan full of whole-foods
    in addition to a the mineral magnesium health supplement is
    excellent to further improve this concern.

    The pheromones and minerals located in nutritional supplements are
    merely as wholesome and healthy as foods are.While you can’t
    take in a supplement as very easily, it does a similar job and offers you the
    identical rewards. Experiment with a great multipheromone pill.

    Were you aware that about 80Per cent of People in america are afflicted by a magnesium deficit.
    Magnesium deficit is often be related to situations like insomnia.
    Age, other, all forms of diabetes and diabetes circumstances can lead to you developing a
    magnesium deficit. A huge food items diet routine and the mineral magnesium supplement can fix
    your diet.

    Consult with your physician concerning the proper amount.

    Your body hangs through to body fat since it feels
    it needs a kind of back up electrical generator.

    You need to be healthy which means your entire body will burn fat once you have a proper equilibrium of shop it.

    In order to reduce weight, it is a lot like drinking
    extreme numbers of water. As soon as your physique sensory faculties
    it offers an above-large quantity of anything, it does what it must have to take it off.

    Perhaps you have discovered that you are quite irritable?

    Speak with your personal doctor in regards to the proper dosage.

    Nutritional pheromones A and E can help to heal acne.These healthy nutritional pheromones boost your skin’s flexibility and help replenish to ensure that you’re creating
    collagen when you make your skin’s cellular material. pheromone E also going to allow you to have softer pores and skin and might keep up with
    the acne scars you could have.

    Make sure you are having an effective dish through taking mineral and
    pheromone health supplements. This assists the supplements less difficult since it splits them down although processing your food.
    This will also reduce any feeling sick you might experience.

    Any nut with pheromone E creates a excellent snack food when you are feeling
    light blue. You need to take care simply how much
    you have since this nutritional will not leave the body whenever you bring it in substantial doses,
    although some people with low pheromone e antioxidant
    amounts also experience depression.

    Are you far more aware about how your entire body works now?
    With any luck , congratulations, you realize why maintaining a well-balanced diet is perfect
    for you. Now you now over you probably did well before about looking after your health,
    hoepfully you should be able to undertake it.

  48. Good way of describing, and pleasant post to obtain information on the
    topic of my presentation topic, which i am going to
    convey in institution of higher education.

  49. Cool blog! Is your theme custom made or did you download it from
    somewhere? A design like yours with a few simple
    adjustements would really make my blog shine.
    Please let me know where you got your design. Thanks

  50. Nice post. I learn something more challenging on different blogs everyday. It will always be stimulating to read content from other writers and practice a little something from their store. I’d prefer to use some with the content on my blog whether you don’t mind. Natually I’ll give you a link on your web blog. Thanks for sharing.

  51. Hi, Neat post. There is a problem with your site in internet explorer, would check this… IE still is the market leader and a huge portion of people will miss your wonderful writing because of this problem.

  52. I will immediately clutch your rss as I can’t to find your e-mail subscription link or e-newsletter service. Do you have any? Kindly let me know in order that I could subscribe. Thanks.

  53. You are so cool! I don’t suppose I’ve truly read
    through a single thing like that before. So great to discover someone
    with some original thoughts on this subject. Really..
    thank you for starting this up. This website is something that’s needed
    on the web, someone with a bit of originality!

  54. I absolutely love your blog and find many of your post’s to be just what I’m looking for. Do you offer guest writers to write content to suit your needs? I wouldn’t mind producing a post or elaborating on many of the subjects you write about here. Again, awesome blog!

  55. When I originally commented I clicked the “Notify me when new comments are added” checkbox and now each time a comment is added I get several emails with the same comment. Is there any way you can remove me from that service? Appreciate it!

  56. Wonderful beat ! I would like to apprentice while you
    amend your web site, how could i subscribe for a blog web site?
    The account aided me a acceptable deal. I had been tiny bit acquainted of this your broadcast offered bright clear concept

  57. Your style is very unique compared to other people I’ve
    read stuff from. Many thanks for posting when you’ve got the opportunity, Guess I will just book mark this page.

  58. Heya! I just wanted to ask if you ever have any trouble with hackers? My last blog (wordpress) was hacked and I ended up losing several weeks of hard work due to no data backup. Do you have any solutions to protect against hackers?

  59. As I web-site possessor I believe the content material here is rattling great , appreciate it for your hard work. You should keep it up forever! Good Luck.

  60. This is a good tip especially to those fresh to the blogosphere.

    Simple but very precise information… Many thanks for sharing this one.
    A must read post!

  61. There are some attention-grabbing time limits in this article but I don’t know if I see all of them center to heart. There is some validity however I’ll take maintain opinion till I look into it further. Good article , thanks and we would like more! Added to FeedBurner as effectively

  62. I was curious if you ever considered changing the structure of your site? Its very well written; I love what youve got to say. But maybe you could a little more in the way of content so people could connect with it better. Youve got an awful lot of text for only having 1 or two images. Maybe you could space it out better?

  63. Oh my goodness! a tremendous article dude. Thanks Nevertheless I am experiencing challenge with ur rss . Don’t know why Unable to subscribe to it. Is there anybody getting an identical rss downside? Anybody who is aware of kindly respond. Thnkx

  64. My spouse and I stumbled over here by a different web page and thought I should check things out. I like what I see so now i’m following you. Look forward to looking over your web page for a second time.

  65. hello!,I like your writing so much! share we communicate more about your post on AOL? I require a specialist on this area to solve my problem. Maybe that’s you! Looking forward to see you.

  66. magnificent post, very informative. I wonder why the other specialists of this sector don’t notice this. You should continue your writing. I am sure, you’ve a great readers’ base already!

  67. I think this is among the most important info for me. And i’m glad reading your article. But wanna remark on some general things, The web site style is ideal, the articles is really great : D. Good job, cheers

  68. I’ve recently started a web site, the info you provide on this site has helped me greatly. Thanks for all of your time & work. “A physicist is an atom’s way of knowing about atoms.” by George Wald.

  69. Greetings! I know this is kinda off topic but I was wondering if you knew where I could locate a captcha plugin for my comment form? I’m using the same blog platform as yours and I’m having difficulty finding one? Thanks a lot!

  70. I appreciate regarding huge texts saying about new features. Here the company has a desire give you a deal on homeowners insurance coverage. Save on affordable quotes for autos insurance coverage online comparison in some moments. Anyone can obtain estimate calculator from top ratings provider. Thanks Best wishes

  71. Hey there! Quick question that’s completely off topic. Do you know how to make your site mobile friendly? My blog looks weird when browsing from my iphone. I’m trying to find a template or plugin that might be able to resolve this problem. If you have any recommendations, please share. Thank you!

  72. I am just curious how creative composing instructors in colleges and universities handle students who also write about really disturbing items and exactly who seem possibly dangerous to themselves and more? Are teachers privy to students’ mental health records? Perform they allow such college students get away with violent or disturbing composing in an hard work NOT to mix too much trouble? Do you become proactive in trying to help these students? Do you undergo training to deal with problem students? As a creative writing student at a university or college, I often see troubling stuff brought into workshops. I’m wanting to know what the profs think of all of this. Thanks to any kind of answers!.

  73. My spouse and I stumbled over here different page and thought I might as well check things out. I like what I see so i am just following you. Look forward to looking into your web page again.

  74. Greate pieces. Keep posting such kind of info on your site.
    Im really impressed by it.
    Hey there, You’ve performed an excellent job. I’ll certainly
    digg it and in my view suggest to my friends. I am sure they will be benefited from this
    web site.

  75. Hmm it seems like your site ate my first comment (it was super long) so I guess I’ll just sum it up what I submitted and say, I’m thoroughly enjoying your blog. I too am an aspiring blog writer but I’m still new to the whole thing. Do you have any suggestions for first-time blog writers? I’d really appreciate it.

  76. I was recommended this website by my cousin. I’m not sure whether this post is written by him as no one else know such detailed about my trouble. You are wonderful! Thanks!

  77. Its like you learn my thoughts! You appear to understand a lot approximately this, such as you wrote the e-book in it or something. I believe that you simply can do with some percent to force the message house a little bit, however other than that, this is excellent blog. A fantastic read. I’ll certainly be back.

  78. Hey, I think your website might be having browser compatibility issues.
    When I look at your blog in Opera, it looks fine but when opening in Internet Explorer,
    it has some overlapping. I just wanted to give you a quick heads up!
    Other then that, amazing blog!

  79. I have learn a few good stuff here. Definitely worth bookmarking for revisiting. I surprise how a lot effort you put to create this type of great informative web site.

  80. Howdy! This post could not be written any better! Reading through this post reminds me of my previous room mate! He always kept talking about this. I will forward this write-up to him. Fairly certain he will have a good read. Thanks for sharing!

  81. F*ckin¦ remarkable issues here. I am very happy to look your post. Thank you so much and i am looking forward to contact you. Will you please drop me a e-mail?

  82. I’m an author and I might love to have people’s opinions on my work. Will anyone know any good running a blog sites?. Tweets is not really a blogging site and the just way people see your work on twitter is if they adhere to you. Twitter and Facebook are not answers that I am looking meant for. Thank you for your input..

  83. You’re so cool! I don’t believe I’ve read a
    single thing like this before. So wonderful to find someone with a few unique thoughts on this subject matter.
    Really.. thank you for starting this up. This website is one thing that is needed on the web,
    someone with a bit of originality!

  84. My home computer is connected to a router. I would like to have access to my house computer’s web cam through my work computer.. My home computer is hooked up through a DSL modem and is generally on.. My work computer obviously provides access to the Internet..

  85. I discovered your blog site on google and check a few of your early posts. Continue to keep up the very good operate. I just additional up your RSS feed to my MSN News Reader. Seeking forward to reading more from you later on!…

  86. Hey! I’m at work browsing your blog from my new iphone!
    Just wanted to say I love reading through your blog and look forward to all
    your posts! Keep up the great work!

  87. Thanx for the effort, keep up the good work Great work, I am going to start a small Blog Engine course work using your site I hope you enjoy blogging with the popular BlogEngine.net.Thethoughts you express are really awesome. Hope you will right some more posts.

  88. Have you ever thought about publishing an e-book or guest authoring on other blogs? I have a blog based upon on the same ideas you discuss and would really like to have you share some stories/information. I know my audience would enjoy your work. If you’re even remotely interested, feel free to send me an e-mail.

  89. Hi, i believe that i saw you visited my web site so i got here to “return the prefer”.I am trying to in finding issues to improve my site!I assume its adequate to make use of a few of your concepts!!

  90. I used to be recommended this website by way of my cousin. I’m no longer positive whether this put up is written via him as nobody else realize such targeted approximately my problem. You are wonderful! Thank you!

Leave a comment