Can Brain Scans Discriminate Children with Autism from Children with Typical Development?

In a recent study, Dr. Lucina Uddin and colleagues found magnetic resonance imaging (MRI) scans to accurately differentiate children with autism spectrum disorders (ASD) from children with typical development based on volumes of gray matter in specific regions of the brain. While previous MRI studies have identified differences in the brain scans of children with ASD and children with typical development, there has been no real consensus regarding which distinctive neurological features can serve as reliable biological markers in the detection of ASD. This may stem from the fact that ASD is a heterogeneous disorder that likely affects the development of many areas of the brain. For this reason, Dr. Uddin and colleagues used MRI scans in an attempt to identify brain regions that together may differentiate children with ASD from children with typical development.

Participants included 24 children with ASD, ages 8-18 years, and 24 children with typical development matched on age, gender, and IQ. All participants underwent MRI scans. Two statistical approaches (voxel-based morphometry and multivariate pattern analysis) were used to analyze the MRI images and identify brain regions that distinguish the participants with ASD from the participants with typical development. Furthermore, Dr. Lucina Uddin and colleagues investigated whether distinctive brain structures were associated with ASD severity, as measured by the Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS).

The results revealed that the participants with ASD and the participants with typical development could be distinguished with up to 90% accuracy based on differences in the volumes of gray matter in specific regions of the brain. The most significant brain regions identified in this study included the posterior cingulate cortex, medial prefrontal cortex, and bilateral medial temporal lobes. These areas of the brain make up the default mode network, which is responsible for internal processes like self-reflection. Moreover, a relationship was identified between ASD severity and the volume of gray matter in posterior cingulate cortex, again a region of the default mode network.

Dr. Uddin and colleagues offer preliminary evidence of biological markers in the brain that may be useful in detecting ASD as well as measuring symptom severity. Currently, ASD is diagnosed based on behavioral evaluations, which can be a lengthy process for many families. Such diagnostic hurdles often delay children with ASD from beginning early intensive behavioral intervention (EIBI) services, which research has shown to be more effective if delivered at earlier ages. Indentifying reliable biological markers for ASD is important as it may improve early detection of the disorder, thus allowing children to receive services earlier.

References

Uddin, L. Q., Menon, V., Young, C. B., Ryali, S., Chen, T., Khouzam, A., … Hardan, A. Y. (in press). Multivariate searchlight classification of structural magnetic resonance imaging in children and adolescents with autism. Biological Psychiatry. doi: 10.1016/j.biopsych.2011.07.014

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  90. Hello! I know this is somewhat off topic but I was wondering which blog platform are you using for this site? I’m getting tired of WordPress because I’ve had issues with hackers and I’m looking at alternatives for another platform. I would be fantastic if you could point me in the direction of a good platform.

  91. Wonderful blog you have here but I was curious about if you knew of any discussion boards that cover the same topics talked about here? I’d really love to be a part of online community where I can get comments from other knowledgeable individuals that share the same interest. If you have any recommendations, please let me know. Thank you!

  92. Today, I went to the beachfront with my kids. I found a sea shell and gave it to my 4 year old daughter and said “You can hear the ocean if you put this to your ear.” She placed the shell to her ear and screamed. There was a hermit crab inside and it pinched her ear. She never wants to go back! LoL I know this is completely off topic but I had to tell someone!

  93. Hello, I think your website might be having browser compatibility issues. When I look at your blog site in Firefox, it looks fine but when opening in Internet Explorer, it has some overlapping. I just wanted to give you a quick heads up! Other then that, awesome blog!

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  95. Hello there! I know this is kind of off topic but I was wondering which blog platform are you using for this website? I’m getting sick and tired of WordPress because I’ve had problems with hackers and I’m looking at options for another platform. I would be awesome if you could point me in the direction of a good platform.

  96. Hey I know this is off topic but I was wondering if you knew of any widgets I could add to my blog that automatically tweet my newest twitter updates. I’ve been looking for a plug-in like this for quite some time and was hoping maybe you would have some experience with something like this. Please let me know if you run into anything. I truly enjoy reading your blog and I look forward to your new updates.

  97. Sweet blog! I found it while searching on Yahoo News. Do you have any tips on how to get listed in Yahoo News? I’ve been trying for a while but I never seem to get there! Thanks

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  100. Hey would you mind stating which blog platform you’re working with? I’m planning to start my own blog soon but I’m having a hard time choosing between BlogEngine/Wordpress/B2evolution and Drupal. The reason I ask is because your design seems different then most blogs and I’m looking for something unique. P.S Apologies for being off-topic but I had to ask!

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  109. With havin so much content and articles do you ever run into any problems of plagorism or copyright violation? My site has a lot of exclusive content I’ve either created myself or outsourced but it seems a lot of it is popping it up all over the web without my authorization. Do you know any ways to help reduce content from being stolen? I’d really appreciate it.

  110. I am really loving the theme/design of your blog. Do you ever run into any browser compatibility problems? A couple of my blog visitors have complained about my site not working correctly in Explorer but looks great in Opera. Do you have any tips to help fix this problem?

  111. Hello there! This is my first visit to your blog! We are a group of volunteers and starting a new initiative in a community in the same niche. Your blog provided us useful information to work on. You have done a wonderful job!

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  113. Hello there! Quick question that’s totally off topic. Do you know how to make your site mobile friendly? My web site looks weird when viewing from my iphone. I’m trying to find a template or plugin that might be able to correct this issue. If you have any suggestions, please share. Cheers!

  114. Greetings from Idaho! I’m bored at work so I decided to browse your website on my iphone during lunch break. I really like the knowledge you present here and can’t wait to take a look when I get home. I’m surprised at how quick your blog loaded on my cell phone .. I’m not even using WIFI, just 3G .. Anyways, good site!

  115. I’m truly enjoying the design and layout of your website. It’s a very easy on the eyes which makes it much more enjoyable for me to come here and visit more often. Did you hire out a developer to create your theme? Exceptional work!

  116. Howdy, i read your blog occasionally and i own a similar one and i was just wondering if you get a lot of spam feedback? If so how do you stop it, any plugin or anything you can suggest? I get so much lately it’s driving me crazy so any support is very much appreciated.

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  120. I’m really enjoying the design and layout of your website. It’s a very easy on the eyes which makes it much more enjoyable for me to come here and visit more often. Did you hire out a developer to create your theme? Great work!

  121. Hmm is anyone else encountering problems with the images on this blog loading? I’m trying to figure out if its a problem on my end or if it’s the blog. Any feedback would be greatly appreciated.

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  123. Today, while I was at work, my cousin stole my iPad and tested to see if it can survive a thirty foot drop, just so she can be a youtube sensation. My apple ipad is now destroyed and she has 83 views. I know this is completely off topic but I had to share it with someone!

  124. Hello there! This is my 1st comment here so I just wanted to give a quick shout out and say I really enjoy reading through your articles. Can you suggest any other blogs/websites/forums that cover the same subjects? Thanks a lot!

  125. Hey I know this is off topic but I was wondering if you knew of any widgets I could add to my blog that automatically tweet my newest twitter updates. I’ve been looking for a plug-in like this for quite some time and was hoping maybe you would have some experience with something like this. Please let me know if you run into anything. I truly enjoy reading your blog and I look forward to your new updates.

  126. Does your blog have a contact page? I’m having trouble locating it but, I’d like to send you an e-mail. I’ve got some suggestions for your blog you might be interested in hearing. Either way, great site and I look forward to seeing it expand over time.

  127. With havin so much content and articles do you ever run into any issues of plagorism or copyright infringement? My website has a lot of exclusive content I’ve either created myself or outsourced but it looks like a lot of it is popping it up all over the web without my agreement. Do you know any methods to help stop content from being stolen? I’d definitely appreciate it.

  128. Hey I know this is off topic but I was wondering if you knew of any widgets I could add to my blog that automatically tweet my newest twitter updates. I’ve been looking for a plug-in like this for quite some time and was hoping maybe you would have some experience with something like this. Please let me know if you run into anything. I truly enjoy reading your blog and I look forward to your new updates.

  129. Hey there! I know this is sort of off-topic however I needed to ask. Does operating a well-established website like yours require a lot of work? I’m completely new to running a blog but I do write in my journal every day. I’d like to start a blog so I can share my personal experience and thoughts online. Please let me know if you have any ideas or tips for brand new aspiring blog owners. Thankyou!

  130. Hey there just wanted to give you a quick heads up. The words in your post seem to be running off the screen in Safari. I’m not sure if this is a format issue or something to do with internet browser compatibility but I thought I’d post to let you know. The design and style look great though! Hope you get the issue solved soon. Kudos

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  135. Hello! I know this is sort of off-topic however I needed to ask. Does operating a well-established website like yours require a large amount of work? I’m brand new to writing a blog but I do write in my journal every day. I’d like to start a blog so I can easily share my personal experience and feelings online. Please let me know if you have any kind of ideas or tips for new aspiring blog owners. Appreciate it!

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  137. Hello would you mind sharing which blog platform you’re using? I’m going to start my own blog in the near future but I’m having a tough time selecting between BlogEngine/Wordpress/B2evolution and Drupal. The reason I ask is because your design and style seems different then most blogs and I’m looking for something unique. P.S My apologies for being off-topic but I had to ask!

  138. Great blog! Do you have any suggestions for aspiring writers? I’m hoping to start my own website soon but I’m a little lost on everything. Would you propose starting with a free platform like WordPress or go for a paid option? There are so many choices out there that I’m totally overwhelmed .. Any suggestions? Kudos!

  139. Have you ever considered publishing an e-book or guest authoring on other blogs? I have a blog based upon on the same subjects you discuss and would really like to have you share some stories/information. I know my audience would enjoy your work. If you are even remotely interested, feel free to shoot me an e mail.

  140. Appreciating the commitment you put into your website and in depth information you offer. It’s nice to come across a blog every once in a while that isn’t the same unwanted rehashed information. Wonderful read! I’ve saved your site and I’m adding your RSS feeds to my Google account.

  141. Do you mind if I quote a couple of your posts as long as I provide credit and sources back to your blog? My website is in the exact same niche as yours and my visitors would genuinely benefit from a lot of the information you provide here. Please let me know if this okay with you. Thanks!

  142. Please let me know if you’re looking for a writer for your weblog. You have some really good articles and I think I would be a good asset. If you ever want to take some of the load off, I’d absolutely love to write some articles for your blog in exchange for a link back to mine. Please blast me an e-mail if interested. Many thanks!

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  144. Hmm is anyone else encountering problems with the images on this blog loading? I’m trying to find out if its a problem on my end or if it’s the blog. Any feed-back would be greatly appreciated.

  145. Hello there I am so glad I found your weblog, I really found you by error, while I was looking on Askjeeve for something else, Anyways I am here now and would just like to say many thanks for a tremendous post and a all round interesting blog (I also love the theme/design), I don’t have time to browse it all at the minute but I have bookmarked it and also included your RSS feeds, so when I have time I will be back to read much more, Please do keep up the fantastic work.

  146. Have you ever considered writing an ebook or guest authoring on other sites? I have a blog based upon on the same subjects you discuss and would really like to have you share some stories/information. I know my viewers would value your work. If you are even remotely interested, feel free to send me an e mail.

  147. Very good blog! Do you have any hints for aspiring writers? I’m planning to start my own website soon but I’m a little lost on everything. Would you recommend starting with a free platform like WordPress or go for a paid option? There are so many choices out there that I’m completely confused .. Any tips? Thank you!

  148. Woah! I’m really loving the template/theme of this website. It’s simple, yet effective. A lot of times it’s tough to get that “perfect balance” between user friendliness and appearance. I must say you have done a excellent job with this. In addition, the blog loads very fast for me on Opera. Superb Blog!

  149. Hi there! I know this is somewhat off topic but I was wondering which blog platform are you using for this website? I’m getting tired of WordPress because I’ve had issues with hackers and I’m looking at options for another platform. I would be great if you could point me in the direction of a good platform.

  150. When I initially commented I clicked the “Notify me when new comments are added” checkbox and now each time a comment is added I get three e-mails with the same comment. Is there any way you can remove me from that service? Thanks!

  151. Hi there! This is kind of off topic but I need some advice from an established blog. Is it tough to set up your own blog? I’m not very techincal but I can figure things out pretty fast. I’m thinking about setting up my own but I’m not sure where to start. Do you have any points or suggestions? Thanks

  152. Hey just wanted to give you a quick heads up and let you know a few of the pictures aren’t loading correctly. I’m not sure why but I think its a linking issue. I’ve tried it in two different internet browsers and both show the same outcome.

  153. Good day! I know this is kinda off topic however , I’d figured I’d ask. Would you be interested in exchanging links or maybe guest authoring a blog article or vice-versa? My blog discusses a lot of the same subjects as yours and I think we could greatly benefit from each other. If you happen to be interested feel free to send me an e-mail. I look forward to hearing from you! Superb blog by the way!

  154. Greetings! I know this is kind of off topic but I was wondering which blog platform are you using for this website? I’m getting sick and tired of WordPress because I’ve had issues with hackers and I’m looking at options for another platform. I would be great if you could point me in the direction of a good platform.

  155. Does your blog have a contact page? I’m having a tough time locating it but, I’d like to send you an email. I’ve got some creative ideas for your blog you might be interested in hearing. Either way, great website and I look forward to seeing it expand over time.

  156. Hello! I understand this is somewhat off-topic however I had to ask. Does building a well-established blog such as yours require a lot of work? I’m completely new to writing a blog but I do write in my diary every day. I’d like to start a blog so I will be able to share my own experience and feelings online. Please let me know if you have any kind of ideas or tips for new aspiring bloggers. Thankyou!

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  162. Hi! This is my first visit to your blog! We are a team of volunteers and starting a new project in a community in the same niche. Your blog provided us useful information to work on. You have done a wonderful job!

  163. Does your site have a contact page? I’m having problems locating it but, I’d like to send you an email. I’ve got some creative ideas for your blog you might be interested in hearing. Either way, great blog and I look forward to seeing it improve over time.

  164. Hmm it seems like your site ate my first comment (it was super long) so I guess I’ll just sum it up what I had written and say, I’m thoroughly enjoying your blog. I as well am an aspiring blog writer but I’m still new to the whole thing. Do you have any points for rookie blog writers? I’d certainly appreciate it.

  165. Write more, thats all I have to say. Literally, it seems as though you relied on the video to make your point. You obviously know what youre talking about, why throw away your intelligence on just posting videos to your site when you could be giving us something informative to read?

  166. Hey there! I know this is somewhat off topic but I was wondering which blog platform are you using for this site? I’m getting tired of WordPress because I’ve had problems with hackers and I’m looking at alternatives for another platform. I would be awesome if you could point me in the direction of a good platform.

  167. Does your blog have a contact page? I’m having problems locating it but, I’d like to shoot you an email. I’ve got some ideas for your blog you might be interested in hearing. Either way, great blog and I look forward to seeing it grow over time.

  168. I really like your blog.. very nice colors & theme. Did you design this website yourself or did you hire someone to do it for you? Plz reply as I’m looking to create my own blog and would like to find out where u got this from. cheers

  169. Whats up are using WordPress for your blog platform? I’m new to the blog world but I’m trying to get started and set up my own. Do you require any coding expertise to make your own blog? Any help would be really appreciated!

  170. Hi there, i read your blog from time to time and i own a similar one and i was just wondering if you get a lot of spam remarks? If so how do you prevent it, any plugin or anything you can suggest? I get so much lately it’s driving me insane so any support is very much appreciated.

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  174. First off I want to say awesome blog! I had a quick question which I’d like to ask if you don’t mind. I was curious to know how you center yourself and clear your head before writing. I have had a difficult time clearing my mind in getting my ideas out. I do take pleasure in writing however it just seems like the first 10 to 15 minutes are generally lost simply just trying to figure out how to begin. Any recommendations or tips? Cheers!

  175. With havin so much content and articles do you ever run into any issues of plagorism or copyright violation? My website has a lot of exclusive content I’ve either written myself or outsourced but it appears a lot of it is popping it up all over the internet without my agreement. Do you know any solutions to help prevent content from being stolen? I’d truly appreciate it.

  176. Hi there this is kind of of off topic but I was wanting to know if blogs use WYSIWYG editors or if you have to manually code with HTML. I’m starting a blog soon but have no coding expertise so I wanted to get guidance from someone with experience. Any help would be enormously appreciated!

  177. Hmm is anyone else encountering problems with the images on this blog loading? I’m trying to determine if its a problem on my end or if it’s the blog. Any suggestions would be greatly appreciated.

  178. Hi would you mind stating which blog platform you’re using? I’m going to start my own blog in the near future but I’m having a hard time deciding between BlogEngine/Wordpress/B2evolution and Drupal. The reason I ask is because your design seems different then most blogs and I’m looking for something completely unique. P.S My apologies for being off-topic but I had to ask!

  179. I am really enjoying the theme/design of your blog. Do you ever run into any internet browser compatibility issues? A small number of my blog readers have complained about my website not working correctly in Explorer but looks great in Safari. Do you have any ideas to help fix this problem?

  180. Whats up this is kind of of off topic but I was wondering if blogs use WYSIWYG editors or if you have to manually code with HTML. I’m starting a blog soon but have no coding skills so I wanted to get guidance from someone with experience. Any help would be greatly appreciated!

  181. Have you ever thought about writing an ebook or guest authoring on other sites? I have a blog based on the same information you discuss and would love to have you share some stories/information. I know my subscribers would enjoy your work. If you are even remotely interested, feel free to shoot me an email.

  182. Do you mind if I quote a couple of your articles as long as I provide credit and sources back to your webpage? My website is in the very same area of interest as yours and my users would definitely benefit from a lot of the information you present here. Please let me know if this alright with you. Cheers!

  183. Hi! Someone in my Facebook group shared this site with us so I came to give it a look. I’m definitely enjoying the information. I’m book-marking and will be tweeting this to my followers! Outstanding blog and great design.

  184. I do not know whether it’s just me or if perhaps everybody else encountering issues with your blog. It appears as if some of the written text within your content are running off the screen. Can someone else please comment and let me know if this is happening to them too? This might be a problem with my web browser because I’ve had this happen before. Thanks

  185. Hi would you mind letting me know which webhost you’re using? I’ve loaded your blog in 3 different internet browsers and I must say this blog loads a lot quicker then most. Can you recommend a good internet hosting provider at a fair price? Many thanks, I appreciate it!

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  187. Hey, I think your site might be having browser compatibility issues. When I look at your blog site in Firefox, it looks fine but when opening in Internet Explorer, it has some overlapping. I just wanted to give you a quick heads up! Other then that, awesome blog!

  188. When I originally commented I clicked the “Notify me when new comments are added” checkbox and now each time a comment is added I get several emails with the same comment. Is there any way you can remove people from that service? Many thanks!

  189. Hi there just wanted to give you a quick heads up. The words in your article seem to be running off the screen in Chrome. I’m not sure if this is a format issue or something to do with browser compatibility but I figured I’d post to let you know. The design and style look great though! Hope you get the issue solved soon. Kudos

  190. Hello excellent blog! Does running a blog like this take a large amount of work? I have absolutely no understanding of coding but I had been hoping to start my own blog soon. Anyway, should you have any suggestions or tips for new blog owners please share. I understand this is off topic however I simply needed to ask. Thank you!

  191. Neat blog! Is your theme custom made or did you download it from somewhere? A design like yours with a few simple adjustements would really make my blog jump out. Please let me know where you got your theme. Cheers

  192. Hello just wanted to give you a quick heads up. The words in your article seem to be running off the screen in Chrome. I’m not sure if this is a formatting issue or something to do with internet browser compatibility but I thought I’d post to let you know. The design and style look great though! Hope you get the problem fixed soon. Many thanks

  193. Hi there! This is my first visit to your blog! We are a group of volunteers and starting a new initiative in a community in the same niche. Your blog provided us useful information to work on. You have done a outstanding job!

  194. Howdy! This post could not be written any better! Reading through this post reminds me of my previous room mate! He always kept chatting about this. I will forward this post to him. Fairly certain he will have a good read. Thank you for sharing!

  195. Excellent blog you have here but I was curious about if you knew of any message boards that cover the same topics talked about here? I’d really like to be a part of community where I can get suggestions from other experienced individuals that share the same interest. If you have any recommendations, please let me know. Bless you!

  196. Woah! I’m really digging the template/theme of this website. It’s simple, yet effective. A lot of times it’s tough to get that “perfect balance” between user friendliness and appearance. I must say you’ve done a very good job with this. Additionally, the blog loads super fast for me on Firefox. Outstanding Blog!

  197. Please let me know if you’re looking for a author for your weblog. You have some really great posts and I feel I would be a good asset. If you ever want to take some of the load off, I’d absolutely love to write some content for your blog in exchange for a link back to mine. Please shoot me an email if interested. Many thanks!

  198. I’m truly enjoying the design and layout of your blog. It’s a very easy on the eyes which makes it much more enjoyable for me to come here and visit more often. Did you hire out a designer to create your theme? Fantastic work!

  199. Hello, i read your blog occasionally and i own a similar one and i was just curious if you get a lot of spam feedback? If so how do you protect against it, any plugin or anything you can advise? I get so much lately it’s driving me mad so any assistance is very much appreciated.

  200. Amazing blog! Is your theme custom made or did you download it from somewhere? A design like yours with a few simple tweeks would really make my blog stand out. Please let me know where you got your design. Kudos

  201. Hi! I could have sworn I’ve been to this blog before but after reading through some of the post I realized it’s new to me. Anyways, I’m definitely happy I found it and I’ll be book-marking and checking back often!

  202. I am really enjoying the theme/design of your blog. Do you ever run into any browser compatibility problems? A handful of my blog audience have complained about my website not working correctly in Explorer but looks great in Firefox. Do you have any advice to help fix this problem?

  203. Today, I went to the beach front with my children. I found a sea shell and gave it to my 4 year old daughter and said “You can hear the ocean if you put this to your ear.” She put the shell to her ear and screamed. There was a hermit crab inside and it pinched her ear. She never wants to go back! LoL I know this is totally off topic but I had to tell someone!

  204. This design is incredible! You most certainly know how to keep a reader entertained. Between your wit and your videos, I was almost moved to start my own blog (well, almost…HaHa!) Excellent job. I really enjoyed what you had to say, and more than that, how you presented it. Too cool!

  205. Hey there, I think your blog might be having browser compatibility issues. When I look at your website in Chrome, it looks fine but when opening in Internet Explorer, it has some overlapping. I just wanted to give you a quick heads up! Other then that, awesome blog!

  206. I know this if off topic but I’m looking into starting my own blog and was curious what all is needed to get set up? I’m assuming having a blog like yours would cost a pretty penny? I’m not very web smart so I’m not 100% positive. Any tips or advice would be greatly appreciated. Kudos

  207. My coder is trying to convince me to move to .net from PHP. I have always disliked the idea because of the expenses. But he’s tryiong none the less. I’ve been using Movable-type on a variety of websites for about a year and am worried about switching to another platform. I have heard good things about blogengine.net. Is there a way I can transfer all my wordpress content into it? Any kind of help would be greatly appreciated!

  208. Hi! This post could not be written any better! Reading this post reminds me of my previous room mate! He always kept chatting about this. I will forward this article to him. Fairly certain he will have a good read. Thanks for sharing!

  209. I’m curious to find out what blog platform you are utilizing? I’m having some minor security problems with my latest site and I would like to find something more safeguarded. Do you have any solutions?

  210. My spouse and I stumbled over here coming from a different page and thought I may as well check things out. I like what I see so now i’m following you. Look forward to looking at your web page yet again.

  211. I love your blog.. very nice colors & theme. Did you design this website yourself or did you hire someone to do it for you? Plz reply as I’m looking to construct my own blog and would like to know where u got this from. cheers

  212. I am really enjoying the theme/design of your weblog. Do you ever run into any internet browser compatibility problems? A small number of my blog visitors have complained about my blog not operating correctly in Explorer but looks great in Opera. Do you have any solutions to help fix this issue?

  213. Hi there would you mind sharing which blog platform you’re working with? I’m looking to start my own blog soon but I’m having a hard time selecting between BlogEngine/Wordpress/B2evolution and Drupal. The reason I ask is because your design and style seems different then most blogs and I’m looking for something unique. P.S Sorry for being off-topic but I had to ask!

  214. I’m not that much of a internet reader to be honest but your sites really nice, keep it up! I’ll go ahead and bookmark your website to come back in the future. All the best

  215. Hello! This is my first comment here so I just wanted to give a quick shout out and say I truly enjoy reading your posts. Can you recommend any other blogs/websites/forums that go over the same subjects? Thanks for your time!

  216. Hello! Do you know if they make any plugins to help with Search Engine Optimization? I’m trying to get my blog to rank for some targeted keywords but I’m not seeing very good results. If you know of any please share. Kudos!

  217. With havin so much content and articles do you ever run into any problems of plagorism or copyright infringement? My blog has a lot of exclusive content I’ve either authored myself or outsourced but it looks like a lot of it is popping it up all over the internet without my agreement. Do you know any techniques to help reduce content from being ripped off? I’d really appreciate it.

  218. Do you mind if I quote a few of your posts as long as I provide credit and sources back to your webpage? My blog site is in the exact same niche as yours and my visitors would really benefit from a lot of the information you present here. Please let me know if this ok with you. Appreciate it!

  219. My spouse and I absolutely love your blog and find nearly all of your post’s to be exactly I’m looking for. Does one offer guest writers to write content for you? I wouldn’t mind composing a post or elaborating on some of the subjects you write about here. Again, awesome web log!

  220. Howdy just wanted to give you a brief heads up and let you know a few of the pictures aren’t loading correctly. I’m not sure why but I think its a linking issue. I’ve tried it in two different internet browsers and both show the same outcome.

  221. I’m not sure exactly why but this site is loading very slow for me. Is anyone else having this issue or is it a issue on my end? I’ll check back later on and see if the problem still exists.

  222. Write more, thats all I have to say. Literally, it seems as though you relied on the video to make your point. You definitely know what youre talking about, why waste your intelligence on just posting videos to your blog when you could be giving us something enlightening to read?

  223. I know this if off topic but I’m looking into starting my own weblog and was wondering what all is required to get set up? I’m assuming having a blog like yours would cost a pretty penny? I’m not very internet savvy so I’m not 100% sure. Any recommendations or advice would be greatly appreciated. Cheers

  224. I’ve been surfing online more than 3 hours today, yet I never found any interesting article like yours. It’s pretty worth enough for me. Personally, if all website owners and bloggers made good content as you did, the net will be a lot more useful than ever before.

  225. Hey! I know this is kinda off topic however , I’d figured I’d ask. Would you be interested in trading links or maybe guest authoring a blog article or vice-versa? My blog covers a lot of the same subjects as yours and I think we could greatly benefit from each other. If you are interested feel free to send me an email. I look forward to hearing from you! Excellent blog by the way!

  226. Hello! I know this is somewhat off topic but I was wondering if you knew where I could find a captcha plugin for my comment form? I’m using the same blog platform as yours and I’m having difficulty finding one? Thanks a lot!

  227. If you say admit to crimes (real or not real) on blog posts, can you be reported to the police and be tried on what is written online?. What if the crime was just a lie, and its a supposed crime you did in another country?.

  228. Hello this is somewhat of off topic but I was wondering if blogs use WYSIWYG editors or if you have to manually code with HTML. I’m starting a blog soon but have no coding expertise so I wanted to get advice from someone with experience. Any help would be greatly appreciated!

  229. Hey there! I just wanted to ask if you ever have any issues with hackers? My last blog (wordpress) was hacked and I ended up losing several weeks of hard work due to no data backup. Do you have any solutions to protect against hackers?

  230. Hmm is anyone else having problems with the images on this blog loading? I’m trying to figure out if its a problem on my end or if it’s the blog. Any feed-back would be greatly appreciated.

  231. Hey there! Quick question that’s totally off topic. Do you know how to make your site mobile friendly? My blog looks weird when viewing from my iphone4. I’m trying to find a template or plugin that might be able to correct this issue. If you have any recommendations, please share. Many thanks!

  232. Howdy just wanted to give you a quick heads up and let you know a few of the pictures aren’t loading properly. I’m not sure why but I think its a linking issue. I’ve tried it in two different internet browsers and both show the same outcome.

  233. Hey! I know this is kinda off topic however I’d figured I’d ask. Would you be interested in exchanging links or maybe guest writing a blog article or vice-versa? My website goes over a lot of the same subjects as yours and I think we could greatly benefit from each other. If you might be interested feel free to send me an email. I look forward to hearing from you! Awesome blog by the way!

  234. Excellent website you have here but I was curious about if you knew of any user discussion forums that cover the same topics discussed in this article? I’d really love to be a part of group where I can get suggestions from other knowledgeable individuals that share the same interest. If you have any recommendations, please let me know. Kudos!

  235. I know this if off topic but I’m looking into starting my own weblog and was wondering what all is required to get setup? I’m assuming having a blog like yours would cost a pretty penny? I’m not very web savvy so I’m not 100% sure. Any recommendations or advice would be greatly appreciated. Kudos

  236. I was wondering if you ever considered changing the layout of your site? Its very well written; I love what youve got to say. But maybe you could a little more in the way of content so people could connect with it better. Youve got an awful lot of text for only having 1 or two images. Maybe you could space it out better?

  237. Fantastic blog! Do you have any hints for aspiring writers? I’m hoping to start my own blog soon but I’m a little lost on everything. Would you advise starting with a free platform like WordPress or go for a paid option? There are so many options out there that I’m completely overwhelmed .. Any recommendations? Many thanks!

  238. Greetings I am so happy I found your website, I really found you by accident, while I was looking on Digg for something else, Anyways I am here now and would just like to say thank you for a tremendous post and a all round exciting blog (I also love the theme/design), I don’t have time to browse it all at the moment but I have saved it and also included your RSS feeds, so when I have time I will be back to read more, Please do keep up the fantastic job.

  239. Appreciating the time and effort you put into your website and detailed information you provide. It’s great to come across a blog every once in a while that isn’t the same outdated rehashed material. Excellent read! I’ve saved your site and I’m adding your RSS feeds to my Google account.

  240. Howdy! This is kind of off topic but I need some guidance from an established blog. Is it hard to set up your own blog? I’m not very techincal but I can figure things out pretty fast. I’m thinking about setting up my own but I’m not sure where to begin. Do you have any points or suggestions? Appreciate it

  241. Hi there fantastic blog! Does running a blog similar to this take a lot of work? I’ve virtually no expertise in coding however I had been hoping to start my own blog in the near future. Anyways, if you have any suggestions or tips for new blog owners please share. I understand this is off subject nevertheless I just wanted to ask. Thanks a lot!

  242. Hey there! I just wanted to ask if you ever have any issues with hackers? My last blog (wordpress) was hacked and I ended up losing months of hard work due to no back up. Do you have any solutions to stop hackers?

  243. Today, while I was at work, my cousin stole my iphone and tested to see if it can survive a 25 foot drop, just so she can be a youtube sensation. My iPad is now destroyed and she has 83 views. I know this is completely off topic but I had to share it with someone!

  244. Today, I went to the beach with my children. I found a sea shell and gave it to my 4 year old daughter and said “You can hear the ocean if you put this to your ear.” She put the shell to her ear and screamed. There was a hermit crab inside and it pinched her ear. She never wants to go back! LoL I know this is totally off topic but I had to tell someone!

  245. It’s a pity you don’t have a donate button! I’d definitely donate to this superb blog! I suppose for now i’ll settle for bookmarking and adding your RSS feed to my Google account. I look forward to brand new updates and will talk about this site with my Facebook group. Chat soon!

  246. My spouse and I absolutely love your blog and find almost all of your post’s to be what precisely I’m looking for. Would you offer guest writers to write content for yourself? I wouldn’t mind publishing a post or elaborating on a few of the subjects you write with regards to here. Again, awesome weblog!

  247. Hey would you mind sharing which blog platform you’re using? I’m going to start my own blog in the near future but I’m having a tough time choosing between BlogEngine/Wordpress/B2evolution and Drupal. The reason I ask is because your design and style seems different then most blogs and I’m looking for something completely unique. P.S My apologies for getting off-topic but I had to ask!

  248. Hmm it appears like your website ate my first comment (it was extremely long) so I guess I’ll just sum it up what I wrote and say, I’m thoroughly enjoying your blog. I too am an aspiring blog blogger but I’m still new to the whole thing. Do you have any helpful hints for newbie blog writers? I’d certainly appreciate it.

  249. Good day! This is my first visit to your blog! We are a team of volunteers and starting a new initiative in a community in the same niche. Your blog provided us useful information to work on. You have done a wonderful job!

  250. Hi there would you mind letting me know which web host you’re working with? I’ve loaded your blog in 3 completely different web browsers and I must say this blog loads a lot quicker then most. Can you recommend a good hosting provider at a fair price? Thanks, I appreciate it!

  251. Hello there I am so delighted I found your weblog, I really found you by mistake, while I was looking on Yahoo for something else, Regardless I am here now and would just like to say kudos for a fantastic post and a all round interesting blog (I also love the theme/design), I don’t have time to go through it all at the moment but I have saved it and also added in your RSS feeds, so when I have time I will be back to read a lot more, Please do keep up the awesome job.

  252. Thanks a bunch for sharing this with all people you actually recognise what you’re speaking about! Bookmarked. Please additionally talk over with my website =). We can have a hyperlink change agreement between us!

  253. Hiya, I am really glad I have found this info. Today bloggers publish only about gossips and internet and this is really frustrating. A good web site with exciting content, that’s what I need. Thanks for keeping this web-site, I’ll be visiting it. Do you do newsletters? Can’t find it.

  254. I was recommended this blog by my cousin. I’m not sure whether this post is written by him as no one else know such detailed about my problem. You are incredible! Thanks!

  255. Hey there just wanted to give you a quick heads up. The text in your content seem to be running off the screen in Ie. I’m not sure if this is a formatting issue or something to do with internet browser compatibility but I thought I’d post to let you know. The layout look great though! Hope you get the problem solved soon. Thanks

  256. Hiya! Quick question that’s completely off topic. Do you know how to make your site mobile friendly? My weblog looks weird when browsing from my iphone 4. I’m trying to find a template or plugin that might be able to correct this problem. If you have any suggestions, please share. With thanks!

  257. Hello there! I know this is kind of off topic but I was wondering if you knew where I could get a captcha plugin for my comment form? I’m using the same blog platform as yours and I’m having problems finding one? Thanks a lot!

  258. Hey superb blog! Does running a blog similar to this take a great deal of work? I have no knowledge of programming however I had been hoping to start my own blog in the near future. Anyway, if you have any ideas or tips for new blog owners please share. I understand this is off topic but I simply needed to ask. Kudos!

  259. Hello, i read your blog from time to time and i own a similar one and i was just curious if you get a lot of spam remarks? If so how do you prevent it, any plugin or anything you can recommend? I get so much lately it’s driving me mad so any assistance is very much appreciated.

  260. First of all I would like to say terrific blog! I had a quick question in which I’d like to ask if you don’t mind. I was interested to know how you center yourself and clear your mind before writing. I have had a tough time clearing my mind in getting my thoughts out. I do take pleasure in writing however it just seems like the first 10 to 15 minutes are wasted just trying to figure out how to begin. Any suggestions or tips? Thank you!

  261. I’m truly enjoying the design and layout of your blog. It’s a very easy on the eyes which makes it much more pleasant for me to come here and visit more often. Did you hire out a developer to create your theme? Outstanding work!

  262. Yesterday, while I was at work, my cousin stole my iPad and tested to see if it can survive a twenty five foot drop, just so she can be a youtube sensation. My apple ipad is now destroyed and she has 83 views. I know this is totally off topic but I had to share it with someone!

  263. When I initially commented I clicked the “Notify me when new comments are added” checkbox and now each time a comment is added I get three emails with the same comment. Is there any way you can remove me from that service? Thank you!

  264. My partner and I stumbled over here from a different website and thought I might check things out. I like what I see so now i am following you. Look forward to going over your web page repeatedly.

  265. This design is spectacular! You certainly know how to keep a reader amused. Between your wit and your videos, I was almost moved to start my own blog (well, almost…HaHa!) Excellent job. I really loved what you had to say, and more than that, how you presented it. Too cool!

  266. Hi are using WordPress for your site platform? I’m new to the blog world but I’m trying to get started and create my own. Do you require any html coding knowledge to make your own blog? Any help would be really appreciated!

  267. Hey I am so grateful I found your blog, I really found you by accident, while I was browsing on Aol for something else, Nonetheless I am here now and would just like to say many thanks for a incredible post and a all round enjoyable blog (I also love the theme/design), I don’t have time to go through it all at the minute but I have bookmarked it and also included your RSS feeds, so when I have time I will be back to read more, Please do keep up the excellent job.

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  269. Hi are using WordPress for your site platform? I’m new to the blog world but I’m trying to get started and set up my own. Do you need any html coding expertise to make your own blog? Any help would be really appreciated!

  270. Fantastic post however , I was wanting to know if you could write a litte more on this subject? I’d be very thankful if you could elaborate a little bit more. Bless you!

  271. Hey! I understand this is somewhat off-topic but I had to ask. Does managing a well-established website such as yours take a lot of work? I’m brand new to operating a blog but I do write in my journal every day. I’d like to start a blog so I can easily share my personal experience and thoughts online. Please let me know if you have any suggestions or tips for brand new aspiring bloggers. Thankyou!

  272. We stumbled over here coming from a different web address and thought I should check things out. I like what I see so now i’m following you. Look forward to checking out your web page for a second time.

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  274. Today, I went to the beach front with my kids. I found a sea shell and gave it to my 4 year old daughter and said “You can hear the ocean if you put this to your ear.” She put the shell to her ear and screamed. There was a hermit crab inside and it pinched her ear. She never wants to go back! LoL I know this is totally off topic but I had to tell someone!

  275. I am curious to find out what blog system you’re using? I’m having some small security problems with my latest blog and I would like to find something more secure. Do you have any solutions?

  276. We are a group of volunteers and starting a new scheme in our community. Your site provided us with valuable info to work on. You have done an impressive job and our entire community will be thankful to you.

  277. I really like your blog.. very nice colors & theme. Did you design this website yourself or did you hire someone to do it for you? Plz respond as I’m looking to create my own blog and would like to know where u got this from. thanks

  278. Does your website have a contact page? I’m having a tough time locating it but, I’d like to shoot you an e-mail. I’ve got some suggestions for your blog you might be interested in hearing. Either way, great site and I look forward to seeing it grow over time.

  279. I’m really enjoying the design and layout of your site. It’s a very easy on the eyes which makes it much more enjoyable for me to come here and visit more often. Did you hire out a designer to create your theme? Great work!

  280. First off I would like to say wonderful blog! I had a quick question that I’d like to ask if you do not mind. I was interested to find out how you center yourself and clear your head prior to writing. I’ve had a hard time clearing my mind in getting my thoughts out there. I do enjoy writing however it just seems like the first 10 to 15 minutes are usually wasted simply just trying to figure out how to begin. Any suggestions or hints? Many thanks!

  281. Wonderful blog! Do you have any tips and hints for aspiring writers? I’m hoping to start my own site soon but I’m a little lost on everything. Would you suggest starting with a free platform like WordPress or go for a paid option? There are so many choices out there that I’m completely confused .. Any ideas? Many thanks!

  282. Please let me know if you’re looking for a writer for your site. You have some really good articles and I feel I would be a good asset. If you ever want to take some of the load off, I’d absolutely love to write some material for your blog in exchange for a link back to mine. Please blast me an email if interested. Cheers!

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  284. With havin so much content and articles do you ever run into any issues of plagorism or copyright violation? My blog has a lot of unique content I’ve either authored myself or outsourced but it looks like a lot of it is popping it up all over the web without my permission. Do you know any techniques to help prevent content from being stolen? I’d certainly appreciate it.

  285. Have you ever thought about publishing an ebook or guest authoring on other blogs? I have a blog centered on the same ideas you discuss and would love to have you share some stories/information. I know my subscribers would enjoy your work. If you’re even remotely interested, feel free to shoot me an email.

  286. I’m really enjoying the theme/design of your website. Do you ever run into any web browser compatibility issues? A small number of my blog audience have complained about my blog not working correctly in Explorer but looks great in Opera. Do you have any solutions to help fix this problem?

  287. Greetings! This is my first comment here so I just wanted to give a quick shout out and tell you I genuinely enjoy reading through your articles. Can you recommend any other blogs/websites/forums that cover the same subjects? Thank you so much!

  288. Hey there! I know this is kinda off topic but I was wondering if you knew where I could get a captcha plugin for my comment form? I’m using the same blog platform as yours and I’m having difficulty finding one? Thanks a lot!

  289. Hey there! I know this is kinda off topic but I was wondering if you knew where I could locate a captcha plugin for my comment form? I’m using the same blog platform as yours and I’m having difficulty finding one? Thanks a lot!

  290. Hello there! This is my first comment here so I just wanted to give a quick shout out and tell you I genuinely enjoy reading through your posts. Can you recommend any other blogs/websites/forums that deal with the same subjects? Thanks a ton!

  291. Hey there I am so excited I found your blog, I really found you by mistake, while I was looking on Askjeeve for something else, Regardless I am here now and would just like to say kudos for a tremendous post and a all round exciting blog (I also love the theme/design), I don’t have time to read through it all at the moment but I have saved it and also added your RSS feeds, so when I have time I will be back to read a lot more, Please do keep up the superb work.

  292. Hi this is somewhat of off topic but I was wondering if blogs use WYSIWYG editors or if you have to manually code with HTML. I’m starting a blog soon but have no coding skills so I wanted to get guidance from someone with experience. Any help would be enormously appreciated!

  293. Hi superb website! Does running a blog like this require a large amount of work? I’ve absolutely no knowledge of coding however I had been hoping to start my own blog soon. Anyhow, should you have any ideas or tips for new blog owners please share. I understand this is off topic nevertheless I just had to ask. Thanks a lot!

  294. Good day! This post could not be written any better! Reading through this post reminds me of my good old room mate! He always kept chatting about this. I will forward this page to him. Fairly certain he will have a good read. Thank you for sharing!

  295. Do you mind if I quote a couple of your posts as long as I provide credit and sources back to your site? My blog is in the exact same area of interest as yours and my visitors would truly benefit from some of the information you provide here. Please let me know if this okay with you. Thanks!

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  297. I’m really enjoying the theme/design of your website. Do you ever run into any browser compatibility problems? A few of my blog visitors have complained about my site not working correctly in Explorer but looks great in Opera. Do you have any suggestions to help fix this issue?

  298. My developer is trying to persuade me to move to .net from PHP. I have always disliked the idea because of the expenses. But he’s tryiong none the less. I’ve been using Movable-type on a number of websites for about a year and am anxious about switching to another platform. I have heard very good things about blogengine.net. Is there a way I can import all my wordpress posts into it? Any kind of help would be really appreciated!

  299. Hello just wanted to give you a quick heads up. The text in your content seem to be running off the screen in Opera. I’m not sure if this is a format issue or something to do with web browser compatibility but I figured I’d post to let you know. The style and design look great though! Hope you get the issue fixed soon. Thanks

  300. Please let me know if you’re looking for a article author for your blog. You have some really good articles and I think I would be a good asset. If you ever want to take some of the load off, I’d really like to write some material for your blog in exchange for a link back to mine. Please send me an e-mail if interested. Many thanks!

  301. Hey excellent blog! Does running a blog such as this take a massive amount work? I have very little knowledge of programming but I was hoping to start my own blog in the near future. Anyways, if you have any recommendations or tips for new blog owners please share. I know this is off topic however I just needed to ask. Thank you!

  302. Hello would you mind stating which blog platform you’re working with? I’m planning to start my own blog in the near future but I’m having a tough time making a decision between BlogEngine/Wordpress/B2evolution and Drupal. The reason I ask is because your design and style seems different then most blogs and I’m looking for something completely unique. P.S Sorry for getting off-topic but I had to ask!

  303. Howdy just wanted to give you a quick heads up. The words in your article seem to be running off the screen in Opera. I’m not sure if this is a formatting issue or something to do with web browser compatibility but I figured I’d post to let you know. The design look great though! Hope you get the problem solved soon. Kudos

  304. Hi this is kind of of off topic but I was wondering if blogs use WYSIWYG editors or if you have to manually code with HTML. I’m starting a blog soon but have no coding knowledge so I wanted to get guidance from someone with experience. Any help would be enormously appreciated!

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